Assessment of Macular thickness Changes in Diabetic Patient
DOI:
https://doi.org/10.69926/nv00y641Keywords:
Diabetes Mellitus, Optical coherence tomography, Central macular thicknessAbstract
Background: Macula is responsible for most of our central vision and normal macular thickness can be change by disease like diabetes that can leads to severe consequences like macular edema, maculopathy and neuronal cell death and result as progressive loss of vision.
Objective: To evaluate the changes in macular thickness of patients suffering from diabetes.
Methodology: This was a cross-sectional study. A total of 178 eyes (89 patients) of diabetes mellitus with a duration of minimum 5 years were included. Patients with Cataract or previous history of cataract, Glaucoma, patient with any other ocular pathology and the patient undergoes laser treatment were excluded from the study. Afterbaseline examination, their funds were evaluated by slit lamp biomicroscope. And all the individual macular thickness assessed by OCT to evaluate the macular thickness changes occurred due to DM.
Results: The study recruited 89 patients between the ages of 40 and 60 years. Among the subjects 42 (47.2%) were male and 47(52.8%) were female. The result of this study showed that mean central macular thickness of right eye was (264.57±66.61) and left eye was (243.90±44.88) and perifoveal region of macula in diabetic patient came out to increases than the mean macular thickness of the healthy cases.
Conclusion: This study showed that CMT is higher in diabetic patients than the control cases. Peripheral macular changes also occurred in diabetic patient t. This shows that the difference was statistically significant. This study also showed that gender and age difference was not statistically significant.
References
Alam U, Asghar O, Azmi S, et al. General aspects of diabetes mellitus. Handbook of clinical neurology 2014;126:211-22.
Khan B, Quraishy MM, Shams A. Central Macular Thickness: A Comparative Study of Diabetics Vs Healthy. Pakistan Journal of Ophthalmology 2019;35(1)
Jha A, Verma A, Alagorie AR. Association of severity of diabetic retinopathy with corneal endothelial and thickness changes in patients with diabetes mellitus. Eye 2022;36(6):1202-08. doi: 10.1038/s41433-021-01606-x
Bouma BE, de Boer JF, Huang D, et al. Optical coherence tomography. Nature Reviews Methods Primers 2022;2(1):79.
Qasim M, Lund A, Urooj S, et al. Comparison of Retinal Thickness between Diabetic patients without Diabetic Retinopathy and Non-Diabetic Controls Using SD-OCT. Pak J Ophthalmol 2024;40(4):420-3.
Sasso FC, Pafundi PC, Gelso A, et al. High HDL cholesterol: A risk factor for diabetic retinopathy? Findings from NO BLIND study. Diabetes research and clinical practice 2019;150:236-44.
Wei Q, Qiu W, Liu Q, et al. Relationship between risk factors and macular thickness in patients with early diabetic retinopathy. International Journal of General Medicine 2022:6021-29.
Liu Y, Huang L, Wang Z, et al. The changes in retinal nerve fiber layer and macular thickness in Chinese patients with alcohol dependency. Drug and Alcohol Dependence 2021;229:109130. doi: https://doi.org/10.1016/j.drugalcdep.2021.109130
Kaye RA, Patasova K, Patel PJ, et al. Macular thickness varies with age-related macular degeneration genetic risk variants in the UK Biobank cohort. Scientific reports 2021;11(1):23255.
Zatreanu L. Macular thickness analysis and resolution of subretinal drusenoid deposits with optical coherence tomography in vitamin A deficiency-related retinopathy. American journal of ophthalmology case reports 2021;21:101023.
Sultan S, Shakeel A, Waris N, et al. Early Visual Recovery in Patients with Diabetic Macular Edema After Giving Intra-vitreal Injection Avastin and Posterior Subtenon Triamcinolone. Annals of King Edward Medical University 2021;27(2)
Ghaffar MT, Anwar F, Bokhari MH, et al. OCT-Based Evaluation of Changes in Retinal Nerve Fiber Layer Thickness following Peeling of Membrane in Patients with Idiopathic Epiretinal Membrane. Annals of Punjab Medical College 2020;14(4):353-56.
Ezhilvendhan K, Shenoy A, Rajeshkannan R, et al. Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography. Journal of Pharmacy and Bioallied Sciences 2021;13(Suppl 2):S1055-S61.
Aitchison RT, Kennedy GJ, Shu X, et al. Measuring central macular thickness in diabetes using swept-source OCT. Investigative Ophthalmology & Visual Science 2019;60(9):2615-15.
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